Cancer and tumor research is very dependent on the successful transplantation of tumors in models, such as zebrafish. The zebrafish models used in the study had a deleted tp53 gene, a tumor suppressor, so that the models were more susceptible to cancer. Angiosarcomas, a fast-spreading tumor commonly found in lymphatic or vascular tissues, are primarily studied. Two methods were compared in studying Angiosarcoma transplantations in the zebrafish models. Single cell dissociation is the process of isolating a cancerous cell for transplant, while tumor engraftment involves cutting a piece of cancerous tissue out of one model and transplanting it into an anesthetized live model in a controlled environment. Tumor transplantation were more successful and the tumors developed faster in zebrafish when researchers used the tumor engraftment method. The angiosarcoma tumor engraftment was 92.8% successful in 3 days while the single cell suspension was 23.8% successful after 22.8 days. This study supports improved Angiosarcoma research by a method for transplanting the tumors in models for study. Developing a more effective method for tumor engraftment in zebrafish could be beneficial for cancerous tissue research and implementation of medicines.